Management of patients receiving novel antithrombotic treatment in endodontic practice: Review and clinical recommendations

Cardiovascular diseases are a major component of non-communicable and death, with thrombosis constituting the most common underlying pathosis three cardiovascular disorders: ischaemic heart disease (acute coronary syndrome), stroke venous thromboembolism (VTE). The introduction direct oral anticoagulants (DOACs) in recent years has necessitated more complex approach to periprocedural perioperative anticoagulation management need for revised strategies protocols. Currently, patients taking classic advised stop drugs have their INR values checked 72 h prior dental surgery (e.g., apical surgery, tooth extraction, periodontal surgery) again 24 procedure ensure it is within therapeutic range. However, current incorporation these novel DOACs routine medical practice requires changes way managed preoperatively dentistry, specifically endodontic surgery. methodology applied this review included searching relevant articles PubMed database using keywords listed Entree Terms databases. Articles published on human blood clotting mechanism, antithrombotic drugs, as well treatment guidelines recommendations dentistry were retrieved. In addition, textbooks that may not surfaced online search searched manually. aim paper was mechanisms action medications impact local haemostasis endodontics.